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Enhancement of O2(subscript)-(superscript) production from resident peritoneal macrophages by low-dose in vivo y(tulisan Yunani)-irradiation.



Tanggal ketik: 20040624, elly. rnDokumentalis: elly. rnSari: Superoxide anion [O2(subscript)-(superscript)] production after very low-dose in vivo irradiation (4cGy) was examined in resident peritoneal macrophages. The level of production rapidly increased following treatment with the PKC activator; phorbol 12-myristate 13-acetate (PMA), but no further enhancement by low-dose in vivo irradiation was observed. On the other hand, treatment with zymosan A gradually induced O2(subscript)-(superscript) production, which was further increased in low-dose in vivo irradiated macrophages. The amounts of phagocytosis of zymosan A were not changed by in vivo irradiation. This indicated that the enhancement of O2(subscript)-(superscript) production was not due to an increase in phagocytotic activity by low-dose in vivo irradiation. Our results show that low-dose in vivo irradiation induces production of reactive oxygen species by macrophages, not only nitric oxide as reported in our previous paper but also O2(subscript)-(superscript). This may contribute to the increase of cytolytic activity of macrophages after low-dose in vivo irradiation.


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Judul Seri
Biological dan Pharmaceutical Bulletin.
No. Panggil
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Penerbit : .,
Deskripsi Fisik
Vol.23 (9) 2000 : 1094-1096.
Bahasa
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Tipe Isi
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Tipe Media
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Tipe Pembawa
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Edisi
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